atuВестник Алматинского технологического университетаThe Journal of Almaty Technological University2304-568X2710-0839АО "АТУ"10.48184/2304-568X-2025-4-15-25atu-2823Research ArticleТЕХНОЛОГИЯ ПИЩЕВОЙ И ПЕРЕРАБАТЫВАЮЩЕЙ ПРОМЫШЛЕННОСТИFOOD AND PROCESSING INDUSTRY TECHNOLOGYРазработка методологии получения растительных фармацевтических субстанций для производства фитопродуктовDevelopment of a methodology for obtaining herbal pharmaceutical substances for the production of phytoproductshttps://orcid.org/0000-0003-1916-8084ИбраеваМ. Б.IbrayevaM. B.

Ибраева Мариям Булатовна - PhD-докторант кафедры инженерных дисциплин и надлежащих практик, Школы фармации, КазНМУ им. С.Д. Асфендиярова.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

ibraevamb2001@gmail.comhttps://orcid.org/0000-0002-8965-7687РысаловаБ. Б.RyssalovaB. B.

Рысалова Балжан Бекбосыновна - PhD-докторант кафедры инженерных дисциплин и надлежащих практик, Школы фармации, КазНМУ им. С.Д. Асфендиярова.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

rysalova.b@kaznmu.kzhttps://orcid.org/0009-0008-0957-9473СабыроваА. Б.SabyrovaA. B.

Сабырова Аружан Бақытжанқызы - PhD-докторант Школы фармации, КазНМУ им. С.Д. Асфендиярова.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

sabyrova-2002@mail.ruhttps://orcid.org/0000-0002-5997-0584ЖумашоваГ. Т.ZhumashovaG. T.

Жумашова Гульсим Токановна - кандидат химических наук, ассоцированный профессор без ученого звания кафедры фармацевтической и токсикологической химии.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

g.zhumashova@mail.ruhttps://orcid.org/0000-0003-4477-4051СакиповаЗ. Б.SakipovaZ. B.

Сакипова Зуриядда Бектемировна - Декан Школы фармации.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

sakipova.z@kaznmu.kzhttps://orcid.org/0009-0003-3689-1757РидвановЧ. И.RidvanovCh. I.

Ридванов Чахо Ибрагимович - руководитель департамента планирования и операционной эффективности ТОО «Абди Ибрахим Глобал Фарм».

040703, с. Мухаметжан Туймебаев, Илийский район, Алматинская область

040703, Mukhametzhan Tuimebayev village, Ili district, Almaty region

info@aigp.kzhttps://orcid.org/0000-0001-7451-0255ОрынбековаС. О.OrynbekovaS. O.

Орынбекова Сауле Оразмуханқызы - лектор кафедры «Инженерных дисциплин и надлежащих практик».

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

saule_04_94@mail.ruhttps://orcid.org/0000-0002-0179-1858СермухамедоваО. В.SermukhamedovaO. V.

Сермухамедова Ольга Владимировна - PhD, директор ТОО «Fitoleum».

050000, Алматы, ул. Толе Би, д. 94; 040400, Есик, ул. М. Маметова, 25

050000, Almaty, 94 Tole Bi str.; 040400, Esik, M. Mametova str., 25

olesia_156@mail.ruДжакияновА. М.JakiyanovA. M.

Джакиянов Амангельды Муратович - PhD докторант, ассистент кафедры биотехнологии и общей химической технологии КазНМУ им. С.Д. Асфендиярова.

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

jakiyanov.a@kaznmu.kzhttps://orcid.org/0009-0009-3052-8176ТуруспаеваЖ. Ж.TuruspayevaZh. Zh.

Туруспаева Жанель Жасланқызы - Магистрант 2 года обучения, образовательная программа: 7М10111- «Фармация».

050000, Алматы, ул. Толе Би, д. 94

050000, Almaty, 94 Tole Bi str.

ibraevamb2001@gmail.comКазахский национальный медицинский университет имени С.Д. АсфендияроваКазахстанKazakh National Medical University S.D. AsfendiyarovKazakhstanТОО «Абди Ибрахим Глобал Фарм»Казахстан«Abdi Ibrahim Global Farm» LLPKazakhstanКазахский национальный медицинский университет имени С.Д. Асфендиярова; ТОО «ФитОлеум»КазахстанKazakh National Medical University S.D. Asfendiyarov; «Fitoleum» LLPKazakhstan20252512202515041525Copyright © Ибраева М.Б., Рысалова Б.Б., Сабырова А.Б., Жумашова Г.Т., Сакипова З.Б., Ридванов Ч.И., Орынбекова С.О., Сермухамедова О.В., Джакиянов А.М., Туруспаева Ж.Ж., 20252025Ибраева М.Б., Рысалова Б.Б., Сабырова А.Б., Жумашова Г.Т., Сакипова З.Б., Ридванов Ч.И., Орынбекова С.О., Сермухамедова О.В., Джакиянов А.М., Туруспаева Ж.Ж.Ibrayeva M.B., Ryssalova B.B., Sabyrova A.B., Zhumashova G.T., Sakipova Z.B., Ridvanov C.I., Orynbekova S.O., Sermukhamedova O.V., Jakiyanov A.M., Turuspayeva Z.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://atu.ejournal.kz/jour/article/view/2823

Современные тенденции развития фармацевтической промышленности характеризуются устойчивым ростом интереса к фитопрепаратам, что связано с повышенным вниманием к безопасности и эффективности лекарственных средств, а также с глобальным стремлением к использованию экологически чистого и возобновляемого сырья. В данных условиях особое значение приобретает разработка научно-обоснованных технологических подходов, направленных на обеспечение стабильности состава и воспроизводимости качества растительной продукции. В представленной работе разработана методология получения лекарственного растительного сырья фармакопейного качества, основанная на применении концепции Quality by Design и инструмента планирования экспериментов (Design of Experiments). Исследования проводились на надземных частях растений Seseli sessiliflorum Schrenk, Dracocephalum bipinnatum Rupr., Dracocephalum integrifolium Bunge, Dracocephalum ruyschiana L. и Ziziphora bungeana Juz., характеризующихся высоким содержанием биологически активных компонетов, включая эфирные масла, флавоноиды и фенольные соединения, обладающие выраженной биологической активностью. В ходе работы была проведена оценка влияния параметров сбора, сушки, измельчения и хранения на сохранность термолабильных компонентов и стабильность химического профиля исследуемого сырья. Разработанная методология получения растительного сырья имеет широкие перспективы для последующей разработки лекарственных препаратов, биологически активных добавок и косметических средств с прогнозируемым качеством и эффективностью, а также для совершенствования системы стандартизации и контроля качества растительных материалов в соответствии с международными требованиями.

Modern trends in the pharmaceutical industry are characterized by a steady increase in interest in herbal remedies, driven by increased attention to the safety and efficacy of drugs, as well as the global desire to use environmentally friendly and renewable raw materials. Under these conditions, the development of scientifically based technological approaches aimed at ensuring the stability of the composition and reproducibility of the quality of herbal products is of particular importance.This paper presents a methodology for obtaining medicinal herbal raw materials of pharmacopoeial quality, based on the application of the Quality by Design concept and the Design of Experiments tool. The studies were carried out using the above-ground parts of the plants Seseli sessiliflorum Schrenk, Dracocephalum bipinnatum Rupr., Dracocephalum integrifolium Bunge, Dracocephalum ruyschiana L. and Ziziphora bungeana Juz., which are characterized by a high content of biologically active components, including essential oils, flavonoids and phenolic compounds with pronounced biological activity. The study assessed the influence of harvesting, drying, grinding, and storage parameters on the preservation of heat-labile components and the stability of the chemical profile of the studied raw materials. The developed methodology for obtaining plant raw materials holds great promise for the subsequent development of drugs, dietary supplements, and cosmetics with predictable quality and effectiveness, as well as for improving the standardization and quality control system for plant materials in accordance with international requirements.

лекарственное растительное сырьеинфракрасное излучениеэфирное маслопланирование экспериментовпараметры технологического процессакачество фармацевтического продуктаmedicinal plant raw materialinfrared radiationessential oildesign of experimentsparameters of technological processquality of the pharmaceutical productThis article was prepared within the framework of the intramural grant project of S.D. Asfendiyarov Kazakh National Medical University “Pharmaceutical development of oral care products based on plant substances for orthodontics.”ReferencesAbubakar, A. R., & Haque, M. (2020). Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes. Journal of pharmacy & bioallied sciences, 12(1), 1–10. https://doi.org/10.4103/jpbs.JPBS_175_19Abubakar, A. R., & Haque, M. (2020). Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes. 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The authors declare that there are no conflicts of interest present.